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1

Effect of Finerenone on Chronic Kidney Disease Outcomes in Type 2 Diabetes

Bakris, George L., Agarwal, Rajiv, Anker, Stefan D., Pitt, Bertram, Ruilope, Luis M., Rossing, Peter, Kolkhof, Peter, Nowack, Christina, Schloemer, Patrick, Joseph, Amer, Filippatos, Gerasimos

Journal:

New England Journal of Medicine

Year:

2020

File:

PDF, 703 KB

2020

2

Failure is an option: learning from unsuccessful proof-of-concept trials

Stefan Schäfer, Peter Kolkhof

Journal:

Drug Discovery Today

Year:

2008

Language:

english

File:

PDF, 96 KB

english, 2008

3

Molecular pharmacology of the mineralocorticoid receptor: Prospects for novel therapeutics

Peter Kolkhof, Steffen A. Borden

Journal:

Molecular and Cellular Endocrinology

Year:

2012

Language:

english

File:

PDF, 419 KB

english, 2012

4

A Luciferase-fragment Complementation Assay to Detect Lipid Droplet-associated Protein-Protein Interactions

Kolkhof, Petra, Werthebach, Michael, van de Venn, Anna, Poschmann, Gereon, Chen, Lili, Welte, Michael, Stühler, Kai, Beller, Mathias

Journal:

Molecular & Cellular Proteomics

Year:

2017

Language:

english

File:

PDF, 4.90 MB

english, 2017

5

Remote Left Ventricular Hemodynamic Monitoring Using a Novel Intracardiac Sensor

Mondritzki, Thomas, Boehme, Philip, White, Jason, Park, Jin Woo, Hoffmann, Jessica, Vogel, Julia, Kolkhof, Peter, Walsh, Stuart, Sandner, Peter, Bischoff, Erwin, Dinh, Wilfried, Hüser, Jörg, Truebel,

Journal:

Circulation Cardiovascular Interventions

Year:

2018

Language:

english

File:

PDF, 1.08 MB

english, 2018

6

[IEEE 2019 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) - Siena, Italy (2019.7.9-2019.7.11)] 2019 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB) - Predicting gene expression level in E. coli from mRNA sequence information

Zhao, Linlin, Abedpour, Nima, Blum, Christopher, Kolkhof, Petra, Beller, Mathias, Kollmann, Markus, Capriotti, Emidio

Year:

2019

Language:

english

File:

PDF, 376 KB

english, 2019

7

Steroidal and non-steroidal mineralocorticoid receptor antagonists in cardiorenal medicine

Agarwal, Rajiv, Kolkhof, Peter, Bakris, George, Bauersachs, Johann, Haller, Hermann, Wada, Takashi, Zannad, Faiez

Journal:

European Heart Journal

Year:

2020

File:

PDF, 1004 KB

2020

8

Identification and optimization of substituted 5-aminopyrazoles as potent and selective adenosine A1 receptor antagonists

Nils Griebenow, Lars Bärfacker, Heinrich Meier, Dirk Schneider, Nicole Teusch, Klemens Lustig, Raimund Kast, Peter Kolkhof

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 901 KB

english, 2010

9

Identification and optimization of tetrahydro-2H-3-benzazepin-2-ones as squalene synthase inhibitors

Nils Griebenow, Timo Flessner, Anja Buchmueller, Martin Raabe, Hilmar Bischoff, Peter Kolkhof

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 454 KB

english, 2011

10

Identification of 4H,6H-[2]benzoxepino[4,5-c][1,2]oxazoles as novel squalene synthase inhibitors

Nils Griebenow, Anja Buchmueller, Peter Kolkhof, Jens Schamberger, Hilmar Bischoff

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 549 KB

english, 2011

11

Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT2) receptor

F Wunder, H Tinel, R Kast, A Geerts, EM Becker, P Kolkhof, J Hütter, J Ergüden, M Härter

Journal:

British Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 659 KB

english, 2010

12

DNA recognition and the code

Müller-Hill, Benno, Kolkhof, Peter

Journal:

Year:

1994

File:

PDF, 158 KB

1994

13

A Basic Tail Increases Repression by Dimeric Lac Repressor

Peter Kolkhof, Stefan Oehler, Regina Alex, Benno Müller-Hill

Journal:

Journal of Molecular Biology

Year:

1995

Language:

english

File:

PDF, 647 KB

english, 1995

14

Lambda cI Repressor Mutants Altered in Transcriptional Activation

Peter Kolkhof, Benno Müller-Hill

Journal:

Journal of Molecular Biology

Year:

1994

File:

PDF, 898 KB

1994

15

Cardiac glycosides potently inhibit C-reactive protein synthesis in human hepatocytes

Peter Kolkhof, Andreas Geerts, Stefan Schäfer, Jan Torzewski

Journal:

Biochemical and Biophysical Research Communications

Year:

2010

Language:

english

File:

PDF, 342 KB

english, 2010

16

Overexpression of PH-4, a novel putative proline 4-hydroxylase, modulates activity of hypoxia-inducible transcription factors

Felix Oehme, Peter Ellinghaus, Peter Kolkhof, Timothy J Smith, Shyam Ramakrishnan, Joachim Hütter, Matthias Schramm, Ingo Flamme

Journal:

Biochemical and Biophysical Research Communications

Year:

2002

Language:

english

File:

PDF, 564 KB

english, 2002

17

Regulation of cyclic adenosine monophosphate release by selective β2-adrenergic receptor stimulation in human terminal failing myocardium before and after ventricular assist device support

Kassner, Astrid, Toischer, Karl, Bohms, Birte, Kolkhof, Peter, Abraham, Getu, Hasenfuβ, Gerd, Morshuis, Michiel, Schulte Eistrup, Sebastian, El-Banayosy, Aly, Gummert, Jan, Milting, Hendrik

Journal:

The Journal of Heart and Lung Transplantation

Year:

2012

Language:

english

File:

PDF, 1.18 MB

english, 2012

18

Aldosterone causes DNA damage in vitro and in kidneys of DOCA/salt rats, mediated by the mineralocorticoid receptor

Nicole Schupp, Peter Kolkhof, Nina Queisser, Lars Bärfacker, Axel Kretschmer, Elke Hartmann, Stefan Schäfer, Helga Stopper

Journal:

Toxicology Letters

Year:

2009

Language:

english

File:

PDF, 61 KB

english, 2009

19

Rationale and design of ARTS: a randomized, double-blind study of BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease

Pitt, Bertram, Filippatos, Gerasimos, Gheorghiade, Mihai, Kober, Lars, Krum, Henry, Ponikowski, Piotr, Nowack, Christina, Kolkhof, Peter, Kim, So-Young, Zannad, Faiez

Journal:

European Journal of Heart Failure

Year:

2012

Language:

english

File:

PDF, 168 KB

english, 2012

20

Mineralocorticoid receptor-mediated DNA damage in kidneys of DOCA-salt hypertensive rats

Schupp, N., Kolkhof, P., Queisser, N., Gartner, S., Schmid, U., Kretschmer, A., Hartmann, E., Oli, R. G., Schafer, S., Stopper, H.

Journal:

The FASEB Journal

Year:

2011

Language:

english

File:

PDF, 364 KB

english, 2011

21

A New Mode of Mineralocorticoid Receptor Antagonism by a Potent and Selective Nonsteroidal Molecule

Fagart, J., Hillisch, A., Huyet, J., Barfacker, L., Fay, M., Pleiss, U., Pook, E., Schafer, S., Rafestin-Oblin, M.-E., Kolkhof, P.

Journal:

Journal of Biological Chemistry

Year:

2010

Language:

english

File:

PDF, 2.83 MB

english, 2010

22

Finerenone, a Novel Selective Nonsteroidal Mineralocorticoid Receptor Antagonist Protects From Rat Cardiorenal Injury

Kolkhof, Peter, Delbeck, Martina, Kretschmer, Axel, Steinke, Wolfram, Hartmann, Elke, Bärfacker, Lars, Eitner, Frank, Albrecht-Küpper, Barbara, Schäfer, Stefan

Journal:

Journal of Cardiovascular Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.16 MB

english, 2014

23

Specificities of three tight-binding Lac repressors

Journal:

Nucleic Acids Research

Year:

1992

Language:

english

File:

PDF, 470 KB

english, 1992

24

Dehydroepiandrosterone-Induced Phosphorylation and Translocation of FoxO1 Depend on the Mineralocorticoid Receptor

Lindschau, C., Kirsch, T., Klinge, U., Kolkhof, P., Peters, I., Fiebeler, A.

Journal:

Year:

2011

Language:

english

File:

PDF, 6.38 MB

english, 2011

25

0278 : Mineralocorticoid receptor antagonism with BR-4628 protects against renal injury induced by ischemia/reperfusion

Le Mercier, Alan, Barrera-Chimal, Jonatan, Prince, Sonia, Fadel, Fouad, El Moghrabi, Soumaya, Kolkhof, Peter, Jaisser, Frederic

Journal:

Archives of Cardiovascular Diseases Supplements

Year:

2015

Language:

english

File:

PDF, 43 KB

english, 2015

26

Effect of Finerenone on Albuminuria in Patients With Diabetic Nephropathy

Bakris, George L., Agarwal, Rajiv, Chan, Juliana C., Cooper, Mark E., Gansevoort, Ron T., Haller, Hermann, Remuzzi, Giuseppe, Rossing, Peter, Schmieder, Roland E., Nowack, Christina, Kolkhof, Peter, J

Journal:

JAMA The Journal of the American Medical Association

Year:

2015

Language:

english

File:

PDF, 520 KB

english, 2015

27

Sulfenic Acid Modification of Endothelin B Receptor is Responsible for the Benefit of a Nonsteroidal Mineralocorticoid Receptor Antagonist in Renal Ischemia

Barrera-Chimal, J., Prince, S., Fadel, F., El Moghrabi, S., Warnock, D. G., Kolkhof, P., Jaisser, F.

Journal:

Journal of the American Society of Nephrology

Year:

2015

Language:

english

File:

PDF, 1.18 MB

english, 2015

28

Aldosterone Causes DNA Strand Breaks and Chromosomal Damage in Renal Cells, Which are Prevented by Mineralocorticoid Receptor Antagonists

Schupp, N., Queisser, N., Wolf, M., Kolkhof, P., Bärfacker, L., Schäfer, S., Heidland, A., Stopper, H.

Journal:

Hormone and Metabolic Research

Year:

2010

Language:

english

File:

PDF, 404 KB

english, 2010

29

Finerenone Impedes Aldosterone-dependent Nuclear Import of the Mineralocorticoid Receptor and Prevents Genomic Recruitment of Steroid Receptor Coactivator-1

Amazit, Larbi, Le Billan, Florian, Kolkhof, Peter, Lamribet, Khadija, Viengchareun, Say, Fay, Michel R., Khan, Junaid A., Hillisch, Alexander, Lombès, Marc, Rafestin-Oblin, Marie-Edith, Fagart, Jérôme

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.97 MB

english, 2015

30

Safety and tolerability of the novel non-steroidal mineralocorticoid receptor antagonist BAY 94-8862 in patients with chronic heart failure and mild or moderate chronic kidney disease: a randomized, double-blind trial

Pitt, B., Kober, L., Ponikowski, P., Gheorghiade, M., Filippatos, G., Krum, H., Nowack, C., Kolkhof, P., Kim, S.-Y., Zannad, F.

Journal:

European Heart Journal

Year:

2013

Language:

english

File:

PDF, 996 KB

english, 2013

31

0316 : Vascular smooth muscle mineralocorticoid receptor contributes to coronary and left ventricular dysfunction after myocardial infarction

Gueret, Alexandre, Harouki, Najah, Galmiche, Guillaume, Favre, J., Nicol, Lionel, Henry, Jean Paul, Besnier, M., Thuillez, Christian, Richard, Vincent, Kolkhof, P., Mulder, Paul, Jaisser, Frédéric, Ou

Journal:

Archives of Cardiovascular Diseases Supplements

Year:

2015

Language:

english

File:

PDF, 51 KB

english, 2015

32

Vascular Smooth Muscle Mineralocorticoid Receptor Contributes to Coronary and Left Ventricular Dysfunction After Myocardial Infarction

Gueret, Alexandre, Harouki, Najah, Favre, Julie, Galmiche, Guillaume, Nicol, Lionel, Henry, Jean-Paul, Besnier, Marie, Thuillez, Christian, Richard, Vincent, Kolkhof, Peter, Mulder, Paul, Jaisser, Fré

Journal:

Year:

2016

Language:

english

File:

PDF, 1.70 MB

english, 2016

33

L’utilisation d’un antagoniste non stéroïdien du récepteur minéralocorticoïde (BR-4628) prévient les lésions rénales induites par l’ischémie-reperfusion

Le Mercier, A., Barrera-Chimal, J., Prince, S., Fadel, F., El, M.S., Kolkhof, P., Jaisser, F.

Journal:

Néphrologie & Thérapeutique

Year:

2015

Language:

french

File:

PDF, 57 KB

french, 2015

34

0542 : Vascular smooth muscle mineralocorticoid receptor contributes to coronary and left ventricular dysfunction after myocardial infarction

Gueret, Alexandre, Harouki, Najah, Favre, Julie, Galmiche, Guillaume, Nicol, Lionel, Henry, Jean-Paul, Thuillez, Christian, Richard, Vincent, Kolkhof, Peter, Mulder, Paul, Ouvrard-Pascaud, Antoine, Ja

Journal:

Archives of Cardiovascular Diseases Supplements

Year:

2016

Language:

english

File:

PDF, 50 KB

english, 2016

35

Differentiation of Arginine Vasopressin Antagonistic Effects by Selective V2 versus Dual V2/V1a Receptor Blockade in a Preclinical Heart Failure Model

Mondritzki, Thomas, Kolkhof, Peter, Sabbah, Hani N, Gheorghiade, Mihai, Fürstner, Chantal, Schmeck, Carsten, Siedentop, Harald, Schaefer, Stefan, Truebel, Hubert

Journal:

American Journal of Therapeutics

Year:

2011

Language:

english

File:

PDF, 340 KB

english, 2011

36

Steroidal and Nonsteroidal Mineralocorticoid Receptor Antagonists Cause Differential Cardiac Gene Expression in Pressure Overload-induced Cardiac Hypertrophy

Grune, Jana, Benz, Verena, Brix, Sarah, Salatzki, Janek, Blumrich, Annelie, Höft, Beata, Klopfleisch, Robert, Foryst-Ludwig, Anna, Kolkhof, Peter, Kintscher, Ulrich

Journal:

Journal of Cardiovascular Pharmacology

Year:

2016

Language:

english

File:

PDF, 1.03 MB

english, 2016

37

Nonsteroidal antagonists of the mineralocorticoid receptor

Kolkhof, Peter, Nowack, Christina, Eitner, Frank

Journal:

Current Opinion in Nephrology & Hypertension

Year:

2015

Language:

english

File:

PDF, 2.27 MB

english, 2015

38

[Handbook of Experimental Pharmacology] || Steroidal and Novel Non-steroidal Mineralocorticoid Receptor Antagonists in Heart Failure and Cardiorenal Diseases: Comparison at Bench and Bedside

Year:

2016

Language:

english

File:

PDF, 731 KB

english, 2016

39

A Randomized Controlled Study of Finerenone vs. Eplerenone in Japanese Patients With Worsening Chronic Heart Failure and Diabetes and/or Chronic Kidney Disease

Sato, Naoki, Ajioka, Masayoshi, Yamada, Takahisa, Kato, Masaharu, Myoishi, Masafumi, Yamada, Takashi, Kim, So-Young, Nowack, Christina, Kolkhof, Peter, Shiga, Tsuyoshi

Journal:

Circulation Journal

Year:

2016

Language:

english

File:

PDF, 965 KB

english, 2016

40

A randomized controlled study of finerenone versus placebo in Japanese patients with type 2 diabetes mellitus and diabetic nephropathy

Katayama, Shigehiro, Yamada, Daishiro, Nakayama, Mikihiro, Yamada, Takashi, Myoishi, Masafumi, Kato, Masaharu, Nowack, Christina, Kolkhof, Peter, Yamasaki, Yoshimitsu

Journal:

Journal of Diabetes and its Complications

Year:

2017

Language:

english

File:

PDF, 386 KB

english, 2017

41

Benefit of Mineralocorticoid Receptor Antagonism in AKI: Role of Vascular Smooth Muscle Rac1

Barrera-Chimal, Jonatan, André-Grégoire, Gwennan, Nguyen dinh Cat, Aurelie, Lechner, Sebastian M., Cau, Jérôme, Prince, Sonia, Kolkhof, Peter, Loirand, Gervaise, Sauzeau, Vincent, Hauet, Thierry, Jais

Journal:

Journal of the American Society of Nephrology

Year:

2017

Language:

english

File:

PDF, 1.88 MB

english, 2017

42

Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury–Mediated Chronic Kidney DiseaseNovelty and Significance

Lattenist, Lionel, Lechner, Sebastian M., Messaoudi, Smail, Le Mercier, Alan, El Moghrabi, Soumaya, Prince, Sonia, Bobadilla, Norma A., Kolkhof, Peter, Jaisser, Frédéric, Barrera-Chimal, Jonatan

Journal:

Year:

2017

Language:

english

File:

PDF, 1.49 MB

english, 2017

43

30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development

Kolkhof, Peter, Bärfacker, Lars

Journal:

Journal of Endocrinology

Year:

2017

Language:

english

File:

PDF, 1.58 MB

english, 2017

44

Lipid droplet subset targeting of the Drosophila protein CG2254/dmLdsdh1

Thul, Peter J., Tschapalda, Kirsten, Kolkhof, Petra, Thiam, Abdou Rachid, Oberer, Monika, Beller, Mathias

Journal:

Journal of Cell Science

Year:

2017

Language:

english

File:

PDF, 3.69 MB

english, 2017

45

Comments on: Lyubarova, R. and Gosmanova, E.O. Mineralocorticoid Receptor Blockade in End-Stage Renal Disease. Current Hypertension Reports, 2017. 19(5)

Gay, Alain, Kolkhof, Peter

Journal:

Current Hypertension Reports

Year:

2017

Language:

english

File:

PDF, 894 KB

english, 2017

46

Aldosterone Target NGAL (Neutrophil Gelatinase–Associated Lipocalin) Is Involved in Cardiac Remodeling After Myocardial Infarction Through NFκB Pathway

Martínez-Martínez, Ernesto, Buonafine, Mathieu, Boukhalfa, Ines, Ibarrola, Jaime, Fernández-Celis, Amaya, Kolkhof, Peter, Rossignol, Patrick, Girerd, Nicolas, Mulder, Paul, López-Andrés, Natalia, Ouvr

Journal:

Year:

2017

Language:

english

File:

PDF, 1.23 MB

english, 2017

47

Transcutaneous glomerular filtration rate measurement in a canine animal model of chronic kidney disease

Mondritzki, Thomas, Steinbach, Sarah M.L., Boehme, Philip, Hoffmann, Jessica, Kullmann, Maximilian, Schock-Kusch, Daniel, Vogel, Julia, Kolkhof, Peter, Sandner, Peter, Bischoff, Erwin, Hüser, Jörg, Di

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2017

Language:

english

File:

PDF, 993 KB

english, 2017

48

The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling

Barrera-Chimal, Jonatan, Estrela, Gabriel R., Lechner, Sebastian M., Giraud, Sébastien, El Moghrabi, Soumaya, Kaaki, Shiem, Kolkhof, Peter, Hauet, Thierry, Jaisser, Frédéric

Journal:

Kidney International

Year:

2018

Language:

english

File:

PDF, 2.39 MB

english, 2018

49

Short- and long-term administration of the non-steroidal mineralocorticoid receptor antagonist finerenone opposes metabolic syndrome-related cardio-renal dysfunction

Lachaux, Marianne, Barrera-Chimal, Jonatan, Nicol, Lionel, Rémy-Jouet, Isabelle, Renet, Sylvanie, Dumesnil, Anais, Wecker, Didier, Richard, Vincent, Kolkhof, Peter, Jaisser, Frederic, Ouvrard-Pascaud,

Journal:

Diabetes, Obesity and Metabolism

Year:

2018

Language:

english

File:

PDF, 1.08 MB

english, 2018

50

The novel mineralocorticoid receptor antagonist finerenone attenuates neointima formation after vascular injury

Dutzmann, Jochen, Musmann, Robert-Jonathan, Haertlé, Marco, Daniel, Jan-Marcus, Sonnenschein, Kristina, Schäfer, Andreas, Kolkhof, Peter, Bauersachs, Johann, Sedding, Daniel G., Alvarez de la Rosa, Di

Journal:

Year:

2017

Language:

english

File:

PDF, 5.98 MB

english, 2017

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